منابع مشابه
Synthesis, labeling and quality control of a new Neuropeptide Y analogue for diagnosis of breast tumors
Introduction: Over expression of selected peptide receptors in human tumors has been shown to represent clinically relevant targets for cancer diagnosis and therapy. The aim of this work was to investigate Neuropeptide Y (NPY) as a new radiopharmaceutical for diagnosis of breast cancer. Methods: A neuropeptide Y analogues with Y1 receptor preference and agonistic p...
متن کاملA Highly Potent Analogue of Oxytocin, Desamino-oxytocin*T
The functional groups in the oxytocin molecule consist, from a chemical standpoint, of a primary amino, a phenolic hydroxyl, three carboxamide groups, and a disulfide linkage. Studies on the relation of structure to biological activity in this and other laboratories have been concerned in part with the significance of these functional groups to the production of a biological response at the sit...
متن کاملA highly potent analogue of oxytocin, desamino-oxytocin.
The functional groups in the oxytocin molecule consist, from a chemical standpoint, of a primary amino, a phenolic hydroxyl, three carboxamide groups, and a disulfide linkage. Studies on the relation of structure to biological activity in this and other laboratories have been concerned in part with the significance of these functional groups to the production of a biological response at the sit...
متن کاملSynthesis and evaluation of a new radiolabeled bombesin analogue for diagnosis of GRP receptor expressing tumors
Introduction: Bombesin (BN), a 14-amino acid neuropeptide, shows high affinity for the human GRP (gastrin releasing peptide) receptors, which are overexpressed by a variety of cancers, including prostate, breast, pancreas, gastrointestinal, and small cell lung cancer. Aim was to prepare [6-hydrazinopyridine-3-carboxylic acid (HYNIC0), D-Tyr6, D...
متن کاملEvaluation of a new bombesin analogue labeled with 99mTc as potential targeted tumor scintigraphic agent
Background: Bombesin shows high affinity for Gastrin-releasing peptide (GRP) receptors which over expressed on the cell surfaces of several human tumors particularly in prostate and breast cancers. The aim of this study was labeling of designed analogue with99mTc via HYNIC and Tricine /EDDA and evaluation as potential targeted tumor scintigraphic agent. Materials and Methods: HYNIC-Bombesin wa...
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1956
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03015280